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TGF-beta and cancer

Research lines

Molecular mechanisms that mediate processes of invasion, angiogenesis and metastasis. Role of TGF-beta in these processes.

Role of oxidative stress in regulating apoptosis. Resistance to such stress in tumor cells.

Role of tumor stem cells in tumor invasion.

ARTICLES 2015- 2016



Crosas-Molist E, Bertran E, Rodriguez-Hernandez I, Herraiz C, Cantelli G, Fabra À, Sanz-Moreno V, Fabregat I.

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.

Oncogene. 2016 Dec 12. doi: 10.1038/onc.2016.454.


Women in Hepatology Group.; Italian Association for the Study of the Liver (AISF).

AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF).

Dig Liver Dis. 2016 Aug;48(8):860-8. doi: 10.1016/j.dld.2016.04.009.

Fabregat I, Malfettone A, Soukupova J.
New Insights into the Crossroads between EMT and Stemness in the Context of Cancer.
J Clin Med. 2016 Mar 12;5(3)

Giannelli G, Mikulits W, Dooley S, Fabregat I, Moustakas A, Ten Dijke P, Portincasa P, Winter P, Janssen R, Leporatti S, Herrera B, Sanchez A.
The Rationale for Targeting TGF-β in Chronic Liver Diseases.
Eur J Clin Invest. 2016 Jan 29.

Moreno-Càceres J, Mainez J, Mayoral R, Martín-Sanz P, Egea G, Fabregat I.
Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1.
FEBS J. 2016 Jan 27.

Fabregat I, Moreno-Càceres J, Sánchez A, Dooley S, Dewidar B, Giannelli G, Ten Dijke P; IT-LIVER Consortium.
TGF-β Signaling and Liver Disease.
FEBS J. 2016 Jan 25.

Dropmann A, Dediulia T, Breitkopf-Heinlein K, Korhonen H, Janicot M, Weber SN, Thomas M, Piiper A, Bertran E, Fabregat I, Abshagen K, Hess J, Angel P, Coulouarn C, Steven D, Meindl-Beinker NM.
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men.
Oncotarget. 2016 Jan 21.

López-Luque J, Caballero-Díaz D, Martinez-Palacián A, Roncero C, Moreno-Càceres J, García-Bravo M, Grueso E, Fernández A, Crosas-Molist E, García-Álvaro M, Addante A, Bertran E, Valverde AM, González-Rodríguez Á, Herrera B, Montoliu L, Serrano T, Segovia JC, Fernández M, Ramos E, Sánchez A, Fabregat I.
Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.
Hepatology. 2016 Feb;63(2):604-19.


Crosas-Molist E, Bertran E, Fabregat I.
Cross-Talk Between TGF-β and NADPH Oxidases During Liver Fibrosis and Hepatocarcinogenesis..
Curr Pharm Des. 2015;21(41):5964-76.

Suárez-Causado A, Caballero-Díaz D, Bertrán E, Roncero C, Addante A, García-Álvaro M, Fernández M, Herrera B, Porras A, Fabregat I, Sánchez A.
HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model.
Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2453-63. doi: 10.1016/j.bbamcr.2015.05.017. Epub 2015 May 20.

García-Álvaro M, Addante A, Roncero C, Fernández M, Fabregat I, Sánchez A, Herrera B.
BMP9-Induced Survival Effect in Liver Tumor Cells Requires p38MAPK Activation.
Int J Mol Sci. 2015 Aug 28;16(9):20431-48.

Crosas-Molist E, Fabregat I.
Role of NADPH oxidases in the redox biology of liver fibrosis.
Redox Biol. 2015 Dec;6:106-11.

Cepeda EB, Dediulia T, Fernando J, Bertran E, Egea G, Navarro E, Fabregat I.
Mechanisms regulating cell membrane localization of the chemokine receptor CXCR4 in human hepatocarcinoma cells.
Biochim Biophys Acta. 2015 May;1853(5):1205-18.

Crosas-Molist E, Meirelles T, López-Luque J, Serra-Peinado C, Selva J, Caja L, Gorbenko Del Blanco D, Uriarte JJ, Bertran E, Mendizábal Y, Hernández V, García-Calero C, Busnadiego O, Condom E, Toral D, Castellà M, Forteza A, Navajas D, Sarri E, Rodríguez-Pascual F, Dietz HC, Fabregat I, Egea G.
Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):960-72.

Fernando J, Malfettone A, Cepeda EB, Vilarrasa-Blasi R, Bertran E, Raimondi G, Fabra À, Alvarez-Barrientos A, Fernández-Salguero P, Fernández-Rodríguez CM, Giannelli G, Sancho P, Fabregat I.
A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells.
Int J Cancer. 2015 Feb 15;136(4):E161-72.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.
Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

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Isabel Fabregat
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